Caffeine Therapy

Caffeine is a model of drug abuse34, and I love it. I don’t know where I’d be without caffeine. Actually I do know where I’d be right now—in bed asleep for the last four hours—but thanks to a strong cup of joe and sugar-free energy drinks, I’ll burn several more hours writing and researching before the caffeine wears off. My name’s Kiefer and I’m a caffeine addict.

For most of my life, I was not a fan of caffeine despite my years in graduate school when my life depended on the ratio of coffee to blood flowing through my veins—a ratio that I’m sure hovered above one most of the time. It wasn’t because of my religion or some other ideology, but because I thought I didn’t need it. Had I only known the potential of coffee’s bitter nectar—it’s true potential that I discovered a few years ago when I began experimenting with Carb Back-Loading™. I figured out that with coffee I could bend the timing of circadian insulin sensitivity to my whim. With caffeine, I no longer need to wait until the evening to eat carbs.

So getting to the gym today exactly at 5pm is not top priority.

Yes, I’ve known this for some time and yes, I was holding out on you when I first introduced Carb Back-Loading. I didn’t throw too many variables out there at once as I knew from experience that I probably wouldn’t explain the basics well enough to begin with. It never escaped me, though I seemed stern on the point of timing your workout, that few people have the luxury of picking their training time with infinite latitude. Let’s be honest: how many people live a life where they can train at the same time every day, a time of their choosing? Not many, including me. Clients and deadlines don’t give a damn when I want to train. I try to start my training session after 3pm; life, however, often dictates otherwise.

This is where caffeine comes in handy. If I need to train earlier in the day than is optimal, I drink caffeine before my session and if the training session runs too long, as part of my post-workout nutrition. I don’t have the caffeine—often in the form of coffee because of the additional cholinomimetic stimulants1,2—because of the cognitive-enhancing abilities3,4, the fat-burning properties5-14, because it increases testosterone levels during training15 and not because recent research shows that caffeine increases nitrous oxide (NO) production16. I don’t even care that caffeine raises your pain threshold, allowing me to push a little harder17-21. I take the caffeine because it decreases my sensitivity to insulin22-30.

Insulin sensitivity is important to health and doctors normally try to help patients increase their sensitivity to insulin and here I am decreasing mine. This is where diet and medical advice gets it wrong. Assumptions about one population cannot applied to all populations out-of-hand. I train heavy. That makes me different from 85% of the U.S. population. Someone who’s sedentary and overweight would be advised to stay clear of the morning caffeine. For those Americans who don’t resistance train, that early morning latte loaded with sugar and caffeine is accelerating their impending diabetes; nothing like loading the body with sugar, turning off the “safe” routes of storage and metabolism, and causing early-onset neuropathy and fat accumulation. “I’ll have a scone with that…fat-free, please…I’m watching my figure.”

I don’t understand—I always get the fat-free scone with my jumbo chocotoxic latte.

Getting up to train at 6 am also makes me atypical, and possibly the fact that I don’t get a low-fat scone if I’m going to get a scone at all. So, at that point, I’d be up early, have had no carbs—possibly no food at all—and be loaded with caffeine. Time to train. By having the caffeine, at the end of my workout I am in a state mimicking the evening reduction in insulin sensitivity. My fat cells can’t intake sugar because they’re less responsive to insulin, but my muscle tissue—which is also insulin de-sensitized—can soak up sugar like a sponge because resistance training forces GLUT4 proteins to the surface of the cells. Once the GLUT4 migrate, they can transport sugar regardless of insulin levels. With caffeine and resistance training, you can control which tissue soaks up sugar and which can’t at any time of day. Control is a beautiful thing.

Caffeine use alone does not substitute for true Carb Back-Loading. This is adjunct therapy. If you cannot make your training time fall after 3pm, then this is your best option for simulating the effects. Caffeine therapy to induce the same physiological state as daytime circadian rhythms is powerful, but you still have other issues to deal with, as the hormonal status in the morning—the increased cortisol levels—is not as favorable as in the evening for ingesting carbs.

Example for morning training:

No carbs before training (if you train as soon as you get up, this is pretty easy)

2 cups of coffee (about 400mg of caffeine depending on the cup size)
10g of an isolate and hydrolysate blend (½ scoop of Blend H)
5 grams of creatine

40g of an isolate and hydrolysate blend (2 scoops of Blend H)
5 grams leucine
25 grams of a fast acting carb (rilose, dextrose, maltodextrin) or 2 to 3 ripe (mottled brown) bananas
200mg of caffeine from a powder or one cup of coffee

Afterward, from post-workout until 6pm or so (dinner), stay ultra-low carb. At dinner start eating the carbs. I’ll talk more about what type of carbs you should eat when back-loading in another article.

Even if you’re eating carbs all day, caffeine helps refill glycogen stores.

In the discussion here, I have primarily focused on simulating the metabolic state that makes Carb Back-Loading such a powerful dietary protocol, but anyone on a carb-based diet can take advantage of caffeine therapy for faster post-training recovery. When ingested as part of a post-workout recovering drink that includes carbohydrates, levels of caffeine around 3.5mg per pound body weight induce a rapid rate of glycogen recovery35,36, stemming, in all likelihood, from the same effect. For a 200 lb male, this would be 700 to 800 mg of caffeine, which, for some, may sound like a lot of caffeine. People generally tolerate intakes up to a gram at a time (1000 mg) well37-42.

Note: I mention coffee throughout the article as a source of caffeine and there are others such as tea, chocolate and guarana. Choose guarana, coffee or energy drinks that specify caffeine for your main sources. Caffeine is a type of methylxanthine found mostly in guarana and coffee beans and is the most potent31,32 (ephedra is not caffeine and is not chemically related). Theophylline is found in teas and theobromine is the type found in chocolate. They all display the same general characteristics and the stronger the type, the shorter duration of effects33. You might be thinking that you should go for the weaker types (from tea and chocolate) and go for the longer effects. It’s a good thought, but you’re better off taking regular doses of the more potent form, and with a Starbucks on every corner, you have no excuse to avoid a regular shot of espresso. You can be an addict too.


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  11. Goldrick RB, McLoughlin GM.  Lipolysis and lipogenesis from glucose in human fat cells of different sizes. Effects of insulin, epinephrine, and theophylline.  J Clin Invest. 1970 Jun;49(6):1213-23.
  12. Raguso CA, Coggan AR, Sidossis LS, Gastaldelli A, Wolfe RR.  Effect of theophylline on substrate metabolism during exercise.  Metabolism. 1996 Sep;45(9):1153-60.
  13. Peters EJ, Klein S, Wolfe RR.  Effect of short-term fasting on the lipolytic response to theophylline.  Am J Physiol. 1991 Oct;261(4 Pt 1):E500-4.
  14. Acheson KJ, Zahorska-Markiewicz B, Pittet P, Anantharaman K, Jequier E.  Caffeine and coffee: their influence on metabolic rate and substrate utilization in normal weight and obese individuals.  Am J Clin Nutr. 1980 May;33(5):989-97.
  15. Beaven CM, Hopkins WG, Hansen KT, Wood MR, Cronin JB, Lowe TE. Dose effect of caffeine on testosterone and cortisol responses to resistance exercise. Int J Sport Nutr Exerc Metab. 2008 Apr;18(2):131-41.
  16. Umemura T, Ueda K, Nishioka K, Hidaka T, Takemoto H, Nakamura S, Jitsuiki D, Soga J, Goto C, Chayama K, Yoshizumi M, Higashi Y. Effects of acute administration of caffeine on vascular function. Am J Cardiol. 2006 Dec 1;98(11):1538-41.
  17. Davis JK, Green JM. Caffeine and anaerobic performance: ergogenic value and mechanisms of action. Sports Med. 2009;39(10):813-32.
  18. Tarnopolsky MA. Effect of caffeine on the neuromuscular system–potential as an ergogenic aid. Appl Physiol Nutr Metab. 2008 Dec;33(6):1284-9. Review.
  19. Green JM, Wickwire PJ, McLester JR, Gendle S, Hudson G, Pritchett RC, Laurent CM. Effects of caffeine on repetitions to failure and ratings of perceived exertion during resistance training. Int J Sports Physiol Perform. 2007 Sep;2(3):250-9.
  20. Tarnopolsky M, Cupido C. Caffeine potentiates low frequency skeletal muscle force in habitual and nonhabitual caffeine consumers. J Appl Physiol. 2000 Nov;89(5):1719-24.
  21. Woolf K, Bidwell WK, Carlson AG. The effect of caffeine as an ergogenic aid in anaerobic exercise. Int J Sport Nutr Exerc Metab. 2008 Aug;18(4):412-29.
  22. Petrie HJ, Chown SE, Belfie LM, Duncan AM, McLaren DH, Conquer JA, Graham TE. Caffeine ingestion increases the insulin response to an oral-glucose-tolerance test in obese men before and after weight loss. Am J Clin Nutr. 2004 Jul;80(1):22-8.
  23. Keijzers GB, De Galan BE, Tack CJ, Smits P. Caffeine can decrease insulin sensitivity in humans. Diabetes Care. 2002 Feb;25(2):364-9.
  24. Greer F, Hudson R, Ross R, Graham T. Caffeine ingestion decreases glucose disposal during a hyperinsulinemic-euglycemic clamp in sedentary humans. Diabetes. 2001 Oct;50(10):2349-54.
  25. Graham TE, Sathasivam P, Rowland M, Marko N, Greer F, Battram D. Caffeine ingestion elevates plasma insulin response in humans during an oral glucose tolerance test. Can J Physiol Pharmacol. 2001 Jul;79(7):559-65.
  26. Thong FS, Graham TE. Caffeine-induced impairment of glucose tolerance is abolished by beta-adrenergic receptor blockade in humans. J Appl Physiol. 2002 Jun;92(6):2347-52.
  27. Thong FS, Derave W, Kiens B, Graham TE, Urso B, Wojtaszewski JF, Hansen BF, Richter EA. Caffeine-induced impairment of insulin action but not insulin signaling in human skeletal muscle is reduced by exercise. Diabetes. 2002 Mar;51(3):583-90.
  28. Robinson LE, Savani S, Battram DS, McLaren DH, Sathasivam P, Graham TE. Caffeine ingestion before an oral glucose tolerance test impairs blood glucose management in men with type 2 diabetes. J Nutr. 2004 Oct;134(10):2528-33.
  29. Johnston KL, Clifford MN, Morgan LM. Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine. Am J Clin Nutr. 2003 Oct;78(4):728-33.
  30. Sachs M, Forster H. Effect of caffeine on various metabolic parameters in vivo. Z Ernahrungswiss. 1984 Sep;23(3):181-205.
  31. Mumford GK, Evans SM, Kaminski BJ, Preston KL, Sannerud CA, Silverman K, Griffiths RR. Discriminative stimulus and subjective effects of theobromine and caffeine in humans. Psychopharmacology (Berl). 1994 Jun;115(1-2):1-8.
  32. Yu G, Maskray V, Jackson SH, Swift CG, Tiplady B. A comparison of the central nervous system effects of caffeine and theophylline in elderly subjects. Br J Clin Pharmacol. 1991 Sep;32(3):341-5.
  33. Arnaud MJ. The pharmacology of caffeine. Prog Drug Res. 1987;31:273-313. Review.
  34. Holtzman SG.  Caffeine as a model drug of abuse.  Trends Pharmacol Sci. 1990 Sep;11(9):355-6. Review.
  35. Pedersen DJ, Lessard SJ, Coffey VG, Churchley EG, Wootton AM, Ng T, Watt MJ, Hawley JA. High rates of muscle glycogen resynthesis after exhaustive exercise when carbohydrate is coingested with caffeine. J Appl Physiol. 2008 Jul;105(1):7-13.
  36. Battram DS, Shearer J, Robinson D, Graham TE. Caffeine ingestion does not impede the resynthesis of proglycogen and macroglycogen after prolonged exercise and carbohydrate supplementation in humans. J Appl Physiol. 2004 Mar;96(3):943-50.
  37. Brice CF, Smith AP. Effects of caffeine on mood and performance: a study of realistic consumption. Psychopharmacology (Berl). 2002 Nov;164(2):188-92.
  38. Greden JF.  Anxiety or caffeinism: a diagnostic dilemma.  Am J Psychiatry. 1974 Oct;131(10):1089-92.
  39. Stern KN, Chait LD, Johanson CE.  Reinforcing and subjective effects of caffeine in normal human volunteers. Psychopharmacology (Berl). 1989;98(1):81-8.
  40. Eaton WW, McLeod J.  Consumption of coffee or tea and symptoms of anxiety.  Am J Public Health. 1984 Jan;74(1):66-8.
  41. Lee MA, Cameron OG, Greden JF.  Anxiety and caffeine consumption in people with anxiety disorders.  Psychiatry Res. 1985 Jul;15(3):211-7.
  42. Rihs M, Muller C, Baumann P.  Caffeine consumption in hospitalized psychiatric patients.  Eur Arch Psychiatry Clin Neurosci. 1996;246(2):83-92.
  • Noob

    I just want to say thank you. For giving me hope that I can get rid of this damn BF and still be strong. I’m starting Carb Nite on Wednesday and hope to be able to send you some before and afters in a few months. I just did my first Powerlifting Comp after 3.5 weeks of training. I hit a 1090 total, weighed in at 280. I hope that Carb nite will get me down to aprpx 240, then I will focus on staying there and gaining muscle. Sorry for rambling, I just get excited by your ideas and writings – I really hope it works for me. Thanks again for all the knowledge sharing.

  • Milan

    Hi Kiefer

    Just want to ask about getting used to caffeine. Will it lose the ability to decrease my sensitivity to insulin? I’m thinking of using it two times a week. No caffeine other days.

  • Kiefer


    The only thing that fades with consistent caffeine use is the hypertension that is initially causes, which is gone after about a week of continuous use. So you can use it daily. Using only twice per week will prevent any chemical addiction that can occur (there is not established psychological addiction).

  • Jon S.


    Really enjoyed this article; it’s great to see you back.

    I’ll try this protocol out for my next morning training session. Two questions; do you find using this specific protocol increases your energy during the rest of the day? You mentioned coffee, tea, energy drinks and powdered caffeine…I’m assuming caffeine tablets would work fine as well?

  • glenn

    great article!

    could you please (if you don’t mind):
    1]provide some other suggestions for ‘whole food’ fast acting carbs [FAC].
    –would any of these work: honey. medjool dates, fresh orange juice.

    1a]it says 25grams FAC, but i’m thinking 2-3 ripe bananas would be more like 40-50grams?

    2]can you mention some ‘whole foods’ that might mimic ‘Blend H’ and/or creatine
    –sorries in advance.. i don’t take supps…
    –ie, whey from cottage cheese, ricotta?
    –ie, creatine from milk, cranberries?

    -related to back carb loading-
    would 1tblspn of lemon juice concentrate in yerbamate/green tea at 5am-ish, not follow suit with ‘back carb loading’? ie, screw it up?

    realize that the supps may be the better answer, just if that wasn’t possible, then what ‘food items’ might you recommend… sorry, i know this breaks with the whole, just run the program as stated : )

    any feedback much appreciated.

  • Hbs6

    Would this apply with someone who works a midnight shift?

  • Curtis

    Would it be beneficial to drink a glass of grapefruit juice to prolong the half-life of the caffeine and open up receptors in the muscle?

  • Kiefer


    1a) I’d go with honey of those choices, but also grapes and bananas spike insulin levels which is what we’re looking for here.

    1b) It takes larger quantities of whole foods to achieve comparable insulin spikes over simple powders.

    2) There are, unfortunately, no foods that you could consume in realistic quantities to achieve the same as a tsp of creatine monohydrate powder. For whey, unless you go for raw, unpasteurized milk, there is no source other than supplements. The heating process require for pasteurization destroys the whey fractions and ALL liquid products derived from milk are pasteurized (even those expensive pre-made whey protein shakes—that’s right, they contain no whey). In either ricotta or cottage cheese the amounts are minimal.

    3) Won’t screw things up.

    I’m not a fan of going all-supplements. I think they should be used only when there is no way to achieve the same results with whole foods. And I can say this: there are no whole foods in the world that can cause the same type of muscular growth and recovery as whey isolates, hydrolysates and casein hydrolysates. I’m not saying you can’t get great results using only whole food, but they will come slower and probably never reach the level of an equivalent athlete using good supplements. So the question becomes: what’s more important, your performance or your dogma? I can’t answer that one, but I can respect if your answer is not performance.

    3) Won’t screw things up.

  • Kiefer


    If your schedule is consistent (say, wake at 6pm, work, then in bed by 10am–chrono-shifted by 12 hours), then yes, this will work. I’ve had the opportunity to work with individuals on the night shift and things stay pretty much the same, just offset by their schedule.

  • glenn

    thanks for the feedback… more a matter of lifestyle than performance (not any ‘dogma’ persay)… i completely understand that ‘real’ supps (utilized properly) are better and/or more efficient for athletes etc etc (zero argument)…

    (sorry just wanted to follow up double check) regards the grams for FAC, am I shooting for 25grams, or 40-50grams ?

    really appreciate the feedback and protocol respectively…

  • okaygoeshere


    I was wondering if store brand instant coffee would work for the caffeine requirement? does it have to be brewed coffee? If so, what do you think about brewing a huge pot and saving it in the fridge for easier usage? Would the caffeine’s integrity still hold up?

    Thanks in advance.

  • Tyson


    The use of caffeine to increase insulin resistence is valid, however, it’s the mechanism by which this occurs that concerns me. Recent (ahead of print) research points to the increased insensitivity being a result of elevated cortisol (which you already know decreases glucose uptake in the periphery). This explains the controversial increase in lipolysis seen with caffeine use without any improvement in anaerobic performance or body composition in studies using caffeine prior to exercise. The meta analysis (2008 and 2009) on the subject are equivocal at best and given the consistently elevated cortisol levels (and decreased testosterone to cortisol ratios) seen in recent studies I’ve switched to decaf.


    • gingeravenger

      Great points, Tyson. I kept wondering when Kiefer was going to address the issue of elevated cortisol levels in this article, but he never did. In my opinion, he lost a lot of credibility in this article by treating caffeine (a drug) as an “end all be all” and conveniently not mentioning the negative hormonal consequences.

  • Richard S

    Great article, I try and keep update with all the knowledge you share Kiefer. I found out this solution from Your article called “Carbs Are Not the Enemy”. Were you going to write another article discussing what kind of carbs we should eat post workout? Or stick to like the Complex Carbs i.e. brown rice, baked potatoes, whole wheat breads, certain fruits? I know my schedule that I have is workout two days (resistance training), and an active rest day of just straight cardio (non-training), which is done as early in the morning as possible. So 2 on, 1 off type of workout program. Though the cardio sessions are intervals, between 30-35 minutes each. The resistance training days the carbs will be low first half then post workout is intaking of carbs? Then on non-training carbs after the run, and then low carb intake till dinner correct? I’m just wanting to make sure and gather more knowledge. Right now I am 6ft weighing in at 150ish pounds. I’m wanting to stay as lean as possible with low body fat. I wouldn’t mind gaining weight, but in muscle mass only, no flab. Thank you for your time sir.

    • Richard S

      “which is done as early in the morning as possible” this was meant towards the cardio sessions, my resistance training is done in the afternoon.

      • kiefer

        You would use caffeine to emulate the processes that govern back-loading if you have to resistance train first thing in the morning. As for cardio, I’m a big believer that it should be done first thing upon waking on an empty stomach, except for a few notable exceptions, like caffeine, MCT oil and possibly a very small amount of whey isolate.

    • kiefer

      Actually, if you’re back-loading properly, you should avoid complex carbs. The subject is covered in greater detail in my upcoming carb back-loading book, but the fastest way to fail or stall with carb back-loading is to make the mistake of applying advice meant for minimal levels of health (like eating low-glycemic carbs, which is poor advice even for health) to performance goals, such as getting jacked.

      • Richard S

        So avoiding complex carbs as I listed will hurt me when I back-load? Is it because of the healthier approach or because of not taking in carbs till post workout? Also when would this book be released? What do you mean “minimal levels of health”? And would low-glycemic carbs be the complex or something else?

        • Richard S

          “So avoiding complex carbs as I listed will hurt me when I back-load?” Correction, So I should avoid complax carbs as I listed? Will they not benefit me for when I back-load?

  • Eric B.

    You are absolutely right on coffee as a hunger suppressor. I never really drank coffee untill I started my new security job at a DESK almost two years ago. When you sit on your butt 8 hrs a day sometimes “food” is…well…something to do. It seems when your job is less “physical” you notice even the tiniest hunger pangs. After spending some time on your carb back-load approach and skipping breakfast I’ve gotta say coffee/espresso has been a lifesaver – hunger saver I should say.

    I remember how sluggish I truly felt when I ate a breakfast. Shoot! Sometimes I felt like going right back to bed afterward! I feel more energetic and whatever I ate the night before holds me over just fine. It’s hilarious the reactions I get when I compare “diets” at work. “No breakfast for me. Just the coffee!”. Reaction- “What?! Breakfast is the most important meal of the day! THAT goes against everything we’ve ever been told!”. That’s why your research sparks my interest. Too many times I’ve seen new things tried over the years and there is never enough time spent on the research itself. Money becomes the top priority so they patent the product or diet and say, “That’s good enough. Let’s get this on the market.”. Then you get a big “WHOOPS! That’s not the miracle diet. This is!!!” a few years later. Keifer you could easily charge people for alot of the info you share on this site(and you’ve got to make money somehow) but tyou don’t and you take time for the public. That’s why I stick around and
    I’m not far enough into the diet yet to testify the “physical” results, but everything else I’m incorporating is proving true. Look forward to the new book so I can see the whole picture from the man himself and NOT all the butchered posts spread across the web portraying carb back-loading.

  • JM3

    Kiefer, I have just ready your ‘when logic doesn’t apply’ article regarding breakfast.
    it says that Leucine stimulates insulin release, would this mean that you wouldn’t suggest using Leucine whilst trying to lose body fat via the carb nite solution?

    • kiefer

      @JM3: Although a ‘yes’ or ‘no’ may seem appropriate here, the answer’s a bit more complex. The simple answer is: don’t use leucine except with a post-workout shake. So, if you don’t train, don’t use leucine at all.

  • Jordan Tarasoff

    Will the fat burning effects of caffeine counteract the reduction in insulin sensitivity in the morning? That is, will I burn more fat throughout the morning if I am insulin sensitive and have high cortisol levels in the morning, but caffeine free? Or will the added caffeine help me burn more fat throughout the morning?

  • Anonymous

    Does the Carb Nite Solution work for type 2 diabetics and is it safe?

    • Anonymous

      It does work for type-2 diabetics, and it will actually improve insulin sensitivity.

      However you should discuss this diet with your doctor!

      • Anonymous

        Thank you. I am waiting for an appt with my doc.
        The only part I worried about was the weekly backloading of carbs. I’ll have to see how far my glucose rises after a carb nite. As my insulin sensitivity improves, maybe the spikes after carb nite won’t be too extreme.

  • Pingback: Carb Backloading: Use Carbs Like Drugs « theYard()

  • Send513b

    Kiefer- my apologies if this has been addressed elsewhere. Anything to the studies that have been done over the years and interpreted as demonstrating that caffeine negates the effect of creatine when the two are taken together? Thanks for all the knowledge you’re putting out there. Jim S.

  • Send513b

    Wanted to re ask my question about creatine/caffeine originally posed below in case it slipped through the cracks. Thanks.

  • Adam Fiddler

    Hey Kiefer,

    Your nutrition protocol is awesome so far–after the first night of carb backloading on the 20-rep squat program I improved my recovery by 300% over baseline (based on the way I quantify things.)

    Would you say there’s a limit on the amount of butter in morning coffee? I’ve been actually doing butter+ MCT + Stevia in my morning coffee but have been on Dave Asprey’s Bulletproof Fasting program and I’m looking to switch over to Carb Back-Loading full time for awhile. Thanks for your opinion.



  • Luke Frye

    Can you use pre workout supplements for your caffeine? I’m not a fan of coffee . I know it would have to be a no carb one.

  • tarius729

    This brings me questions about circadian rhythm. right now i am on a funky schedule where i usually go to bed at 5 or 6 am and wake up in the afternoon around 3 or 4pm. i usually get 200 mgs of caffeine right when i wake up. i start my day, limit my carbs, then train between 9-11pm or later. then i end up carb back loading in the morning, after midnight. is my insulin sensitivity related to the time of day itself, or the hours of time that i have been awake?

    • taruis729

      also, i would love if Kiefer could address Tyson’s concerns below about increased insensitivity being a result of elevated cortisol and the drop in testosterone due to caffeine use. Thanks!!

  • RJ

    I ordered the Blend H from Protein factory. My order did not include a scoop. On the label it states (serving size 2/3 cup) but in your article it has (½ scoop of Blend H).
    Could you help me out ?

  • Adam

    What a about the corresponding increase in cortisol as a result of excess caffeine? Isn’t that not a good mix with insulin spikes (supresses the cortisol HSL capabilities)?


    Hi Kiefer, do you think this statement/study is wrong (it suggests caffeine LOWERS pain threshold significantly):
    Apart from that I agree that introverts have a lower pain threshold and I am sure it is because they are undermethylated (produce less methyl and thereby also less creatine):
    By the way, coffe contains a lot of methyl, so this in it self could increase the pain threshold.